We are less good at—and perhaps less interested in—measuring how drugs improve people's lives. They found that both drugs were able to block the flow of chloride, causing the smooth muscle cells to relax. In a chain reaction, the outward flow of chloride causes calcium to flow into the cells. The contraction is controlled by negatively charged chloride moving from inside the cells to outside. Researchers at the University of Wisconsin-Madison report this month that sildenafil increases the amount of oxytocin released by stimulation of the posterior pituitary gland, a small structure directly underneath the brain that regulates hormone levels in response to neural signals.

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